A variety of odontogenic, nonodontogenic, and inflammatory conditions may occur between the roots of the maxillary canine and lateral incisor. A list of differential diagnoses might include: odontogenic keratocyst, central giant cell granuloma, odontogenic myxoma, primordial cyst, lateral periodontal cyst, ameloblastoma, and radicular cyst. A diagnosis of globulomaxillary cyst should be noticeably absent from the list, however, and should be considered only after clinical radiographic, and microscopic correlation has effectively ruled out all other possibilities.