Eating foods containing sucrose between meals can be highly cariogenic. The use of sucrose substitutes that provide the hedonistic appeal of sucrose, yet are not fermented by the plaque flora to the low pHs that are associated with caries, is a reasonable approach to caries control. Xylitol, a sweet-tasting pentitol, has been reported to cause about an 80% reduction in caries increment when chewed in a gum. The present investigation was designed to determine whether the chewing of xylitol gums affected the salivary and plaque levels of S mutans and lactobacilli. The chewing of xylitol gums for four weeks caused a significant reduction in saliva levels and plaque proportions of S mutans compared with pretreatment values. The levels were also significantly reduced to values obtained by chewing either sorbitol or fructose sweetened gum. The chewing of various gums had no significant effect on the proportions of lactobacilli in the plaque. These findings suggested that the small amounts of xylitol used (about 5 gm) resulted in a suppression of S mutans.

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				P. Milgrom, K.A. Ly, M.C. Roberts, M. Rothen, G. Mueller, and D.K. Yamaguchi Mutans Streptococci Dose Response to Xylitol Chewing Gum J. Dent. Res., February 1, 2006; 85(2): 177 - 181. [Abstract] [Full Text] [PDF]